Prospectus Supplement

Filed Pursuant to Rule 424(b)(3)
Registration No. 333-171998

Prospectus Supplement to Prospectus dated April 23, 2012

InVivo Therapeutics Holdings Corp.

26,047,200 Shares of Common Stock

This prospectus supplement updates the prospectus dated April 23, 2012 relating to the offer for sale of up to an aggregate of 26,047,200 shares of common stock of InVivo Therapeutics Holdings Corp. by the selling securityholders identified in the prospectus and this prospectus supplement, and any of their pledgees, donees, transferees or other successors in interest.

We are providing this prospectus supplement to update the table in the prospectus under the caption “Selling Securityholders” to reflect transfers of warrants to purchase shares of common stock by certain selling securityholders. The amounts set forth below are based upon information provided to us by the selling securityholders (or his or its representatives), or on our records, and are accurate to the best of our knowledge. Unless we indicate otherwise, the information in this prospectus supplement is as of May 10, 2013.

 

Name

   Securities Beneficially Owned
Prior to the Offering
     Securities Offered
Hereby
     Securities Beneficially
Owned After this
Offering
 
   Common
Stock (1)
     Warrants      Common
Stock
     Common
Stock
Underlying

Warrants
     Common
Stock
     Warrants  

Craig Whited

     350,000         220,000         350,000         220,000         —           —     

Matthew Rosenblum

     N/A         130,000         N/A         130,000         N/A         —     

RRC Bio Fund LP (2)

     250,000         N/A         250,000         N/A         —           N/A   

Options Opportunistic Corp.

     N/A         83,000         N/A         83,000         N/A         —     

Warberg Opportunistic Trading Fund LP

     N/A         83,000         N/A         83,000         N/A         —     

Warberg WF I LP

     N/A         84,000         N/A         84,000         N/A         —     

 

(1) Does not include shares of common stock underlying the warrants.
(2) In accordance with Rule 13d-3 under the Exchange Act, James A. Silverman may be deemed a control person of the shares owned by RRC Bio Fund LP, with final voting power and investment control over such shares.

This prospectus supplement is not complete without the prospectus dated April 23, 2012, as supplemented to date, and we have not authorized anyone to deliver or use this prospectus supplement without the prospectus.

The date of this prospectus supplement is May 10, 2013.