InVivo Therapeutics Holdings Corp.

One Kendall Square, Suite B14402

Cambridge, MA 02139


November 17, 2022




Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549


  Re:     InVivo Therapeutics Holdings Corp.
    Registration Statement on Form S-1
    File No. 333-268256
    Request for Acceleration


Ladies and Gentlemen:


Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, InVivo Therapeutics Holdings Corp. hereby requests acceleration of the effective date of its Registration Statement on Form S-1 (File No. 333-268256), so that it may become effective at 4:00 p.m. on November 21, 2022, or as soon thereafter as practicable.


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  Very truly yours,
  By: /s/ Richard Toselli                              
  Name: Richard Toselli
  Title: President and Chief Executive Officer


Signature Page to Acceleration Request